Best Wine Bars In Winston-Salem (2025 Update)

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Winston-Salem is in Yadkin wine country. That means there’s going to be a lot of enthusiasm around wine. Plenty of restaurants offer good wine and have wine specials, but what about dedicated wine bars? Here are our picks.

6th And Vine Restaurant And Wine Bar

6th & Vine is a unique, cozy wine bar with comfy couches and a beautiful patio that is a welcoming place to eat and sip one of the over 25 wines they have by the glass. They also serve local beers and cocktails, and their menu includes sharing plates, entrees, burgers, sandwiches, and salads. A Saturday and Sunday Brunch Menu is available 11am – 3pm. It is a pet-friendly restaurant in the heart of the Downtown Arts District. They have a lovely patio for outdoor seating. Wine flights are available on Wednesday for $15, wine is half-price by the glass ($12 or less) on Thursdays, and half-price by the bottle on Sundays (excludes reserves).

6th and Vine Website

• 209 W 6th Street, Winston-Salem, NC
• 336-725-5577
• Hours
  • Wed & Thurs, 4pm – 8:30pm
  • Fri, 4pm – 9:30pm
  • Sat, 11am – 9:30pm
  • Sun, 11am – 8pm

The Caviste

The Caviste is a wine bar and bottle shop specializing in small wine producers. Different wines than found elsewhere can be had here. Special Events include wine tastings and wine dinners. Comfortable, relaxing spot for wine enjoyment. Snacks are available to accompany your wine.

The Caviste Website

• 1100 Reynolda Road, Winston-Salem, NC
• 336-774-3775
• Hours
  • Tues – Sat, 12pm – 8pm

Little Pep

Little Pep is a new Wine Bar that had its Grand Opening May 11, 2024. Serving wine, all day snacks, and small plates beginning at 5pm, it promises to have something for everyone. They offer a wine club and public wine tastings, so keep an eye on their Instagram page for upcoming events. Stop in and visit this quaint little shop in downtown Winston-Salem.

Little Pep Website | Little Pep Instagram

• 533 N Trade Street, Winston-Salem, NC
• 336-777-6207
• Hours
  • Wed – Sun, 2pm – 10pm

Manolo’s Boutique Wines & Bistro

Enjoy fine Wine and a charming atmosphere in this historic space at The Rosenbacher House. They feature an excellent wine list, appetizers, grazing boards, skewers, salads, and delectable Roman style pizzas with fresh ingredients. Luscious Italian desserts are also served. Wine tasting is held every 1st and 3rd Wednesday, 6-8pm, and Bourbon-tasting nights also happen. They feature live music, including flamenco guitar and dancing, and classical music on certain nights. Follow them on Facebook for upcoming events.

Manolo’s Website | Manolo’s Facebook Page

• 848 W 5th Street, Winston-Salem, NC
• 336-518-6770
• Hours:
  • Tues, 5pm – 9pm (Wine Bar)
  • Wed & Thurs, 5pm – 9pm
  • Fri & Sat, 5pm – 10pm

Melrose Cafe And Wine Lounge

Melrose is a California-inspired coffee and wine bar. Comfortable seating and casual atmosphere. Savory bites and desserts are available.

Melrose Cafe And Wine Lounge Facebook

• 1608 S Stratford Road, Winston-Salem, NC
• 336-448-0116
• Hours
  • Sun-Thurs, 8am – 6pm
  • Fri & Sat, 8am – 8pm

Sir Winston Wine Loft

Sir Winston’s has a full restaurant available but their Wine Loft is perfect if you prefer lighter dining and spirited conversation. There is a casual elegance about Sir Winston and an amazing selection of local and national wines. You can simply sit and sip and enjoy conversation or order delicious appetizers from the small plate menu. Enjoy a delightful evening.

Sir Winston Wine Loft Website

• 104 W 4th Street, Winston-Salem, NC
• 336-722-0795
• Hours
  • Sun – Thurs, 5pm – 10pm
  • Fri & Sat, 5pm – 10pm

STEM Beverage And Supply

STEM is a family-owned bar with a modern vibe. They feature fine wines, cocktails, and draft beers. Caviar is available for snacking.

STEM Website

• 626 W 4th Street, Winston-Salem, NC
• 336-448-5609
• Hours
  • Tues-Sat, 4pm – 12am
  • Sun, 12pm – 7pm

West Salem Public House

WSPH brings delicious beverages into a warm neighborhood meeting place. Their wine list is eclectic but fun. Their beer list focuses on regional and local craft brewing. Coffee is also served until 3 pm.

West Salem Public House Website

• 400 S Green Street, Winston-Salem, NC
• 336-289-9160
• Hours
  • Mon & Tues, 6:30am – 3pm
  • Wed-Fri, 6:30am – 10pm
  • Sat, 8am – 11pm

The Best Yadkin Valley Wineries

Wine lovers, remember we have some beautiful vineyards right in our backyard. See our list of the best Yadkin Valley wineries and visit a few.

Do you know of a wine bar we missed? Let us know in the comments.